I believe the products from nightrider are just plug and play resistors that "trick" the ECM into running richer by switching signals from the O2 sensors. No way to properly tune the bike.
I run them on my 2010 Iron with V&H pipes and a SE air filter kit.
Works beautifully. Much cheaper than a tuner, very easy to fit. I did a LOT of research before getting them, and I'm so happy with their performance that I shall fit them to all my future Harleys.