If you wife is still nerveous on the scoot I would not take her on the Three Sisters. The trip from Medina to Leaky has some very sharp elevated twisties. I sure she would be on edge. Like others have said there is plenty of great riding in the area.
I totally agree with this. If you're wife is not comfortable yet, I would stay off of 337 and 16 north of Medina. Other than that there are still hundreds of miles of great roads in the area.