if you are in the la crosse area stop at the dealer and ask about the mindoro cut, its about 10 min from la crosse hd, only about a 15 minute jaunt, its our tail of the dragon worth the side trip
My wife and I have doen the Great River Road between St. Louis, MO and Redwing, MN. We did the round trip - up the west side of the river and down the east side of the river. Lots of great scenery and many fun places to stop. I'll be doing it again.