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I know that it is a relatively durable machine. Many of the guys I work with take them back and forth from work when working night shifts (we are allowed to sleep on the job). It is probably most important to protect the circuit (the part from machine to your nose) making sure it doesn't crimp. Other then that you should be fine, I can't imagine that the vibration will affect it as these are under the same standards as portable medical equipment and do undergo vibration testing.
Streetmed
06 Streetglide
Upper Darby PA 19082
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2006 Streetglide (vivid black)
Vance and Hines Bigshot true duals w/sharkfinn ends
K&N Stage I
PC III
Lots of chrome
Red Knights Southeastern PA Chp II
Been traveling with mine both on the Harley and my sport bike for years. Never had any problem other than it taking up valuable packing space on trips.
Mine is in my sic pic on top of the Nelson Rigg bag that I carried to Colorado. It was either going there or in the tour pack. I haven't had any problems carrying it, even on the FXRS. The bag was more exposed on the FXRS, but I wrapped the machine up in a trash bag before putting it in the carrying case. I just had some light rain on that trip and it never got wet...